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Flavopiridol Has Significant Activity in Relapsed Chronic

Researchers from Ohio State University have reported that flavopiridol has “pronounded" activity in treating patients with relapsed chronic lymphocytic leukemia (CLL). The details of this study were presented at the 2008 meeting of the American Society of Clinical Oncology in Chicago May 30-June 2.1

Flavopiridol is a cyclin-dependent kinase inhibitior that is being evaluated as a single agent and in combination with other agents for the treatment of CLL. Recent studies suggested that the efficacy of flavopiridol was schedule dependent and associated with the release of IL-6, which led to hyperacute tumor lysis syndrome. This led to the development of a regimen that consisted of a 30-minute loading dose followed by a four-hour infusion that was administered weekly for four to six weeks. more

Get Yourself A Thinking Doctor!

When I asked him how he could be so certain that I was bipolar, and why he insisted on treating me with atypical antipsychotics even though I had difficulty tolerating them in my past, he became quite snippy with me and said, much like Sr. Carol in the third grade with her ruler, "Ms. Borchard. You ARE bipolar. End of story."

The other week when I went to Dr. Smith after a turbulent month, she told me about the growing amount of research suggesting that antidepressants aren't helpful for persons with bipolar disorder who are bothered by depression more than mania (which is just about everyone with bipolar disorder.

"Huh?" I asked. "I don't understand. So then why have you been treating me with antidepressants?"

She smiled (and believe it or not THAT reassures me much more than any fake sermon about how a doctor is going to cure me) and explained her reasoning: given the older research suggesting that antidepressants are helpful, and the clinical experience of herself and those who trained her that antidepressants seem to be helpful in some patients, it is still very reasonable to use them, especially for someone like myself whose manias have been much less dangerous than the depressions. more

Comments on this Story

If the U.S. government believes in it's propaganda about treating people fairly they should be at the forefront in demanding the return of these territories to the Palistinians.

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3. Comment by Peter C. (#4977) — June 24,2008 @ 6:07AM . more

Targanta Therapeutics (TARG) Announces EMEA Accepts Review for

Targanta is seeking approval of intravenous oritavancin in the European Union for the treatment of complicated skin and soft tissue infections caused by gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. Targanta announced the submission of its MAA for oritavancin to EMEA on June 9, 2008. The oritavancin MAA includes data from 19 clinical trials, including two pivotal Phase 3 clinical trials examining the safety and efficacy of intravenous oritavancin in the treatment of cSSTI, both of which met their primary endpoints. The MAA dossier also includes data from more than 2,100 individuals and in vitro activity data on oritavancin against more than 9,000 clinical bacterial isolates, including a broad range of gram-positive strains resistant to commonly used antibiotics such as oxacillin, methicillin, vancomycin, daptomycin, and linezolid. more

Invigorating the US-Turkey Strategic Partnership

But, the continued presence of PKK bases in northern Iraq led many Turkish citizens from all walks of life to resent what they perceived as the U.S. treating Turkey’s primary terrorist (and national security) threat differently than we treated Al Qaida. As a result, the popularity of the United States shrank to record low-levels, reaching a depressing 9 percent in mid-2007.

The November 2007 Oval Office meeting between President Bush and Prime Minister Erdogan marked a decisive turning point. President Bush’s designation of the PKK as "an enemy of Turkey, an enemy of Iraq, and therefore an enemy of the United States," signaled a new approach by Washington. The intensive information sharing authorized by President Bush has opened a new chapter in security cooperation between the United States, Turkey, and Iraq. more

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